Ordering cancer mutational profiles of cross-sectional copy number alterations
نویسندگان
چکیده
منابع مشابه
Evaluation of HER2, MDM2, MYC, MET and TP53 gene copy number alterations in gastric cancer patients
Background: Gastric cancer (GC) is considered as one of the most common types of cancer worldwide with poor prognosis and generally limited treatment options. Recent studies have indicated that HER2, MDM2, MYC, MET, and TP53 play an important role in the development of gastric cancer. Therefore, the aim of this study was to evaluate the incidence of amplification/deletion of these genes in pati...
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Understanding the molecular basis of cancer requires characterization of its genetic defects. DNA microarray technologies can provide detailed raw data about chromosomal aberrations in tumor samples. Computational analysis is needed (1) to deduce from raw array data actual amplification or deletion events for chromosomal fragments and (2) to distinguish causal chromosomal alterations from funct...
متن کاملLessons from a decade of integrating cancer copy number alterations with gene expression profiles
Over the last decade, multiple functional genomic datasets studying chromosomal aberrations and their downstream effects on gene expression have accumulated for several cancer types. A vast majority of them are in the form of paired gene expression profiles and somatic copy number alterations (CNA) information on the same patients identified using microarray platforms. In response, many algorit...
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Motivation and Objectives Cancer is a very complex disease and understanding its dynamics and evolution is one of the challenges of modern biosciences. As most available data on cancer is static, extracting dynamic information about its progression from “static” biological data would have a major significance. We are approaching the Temporal Ordering Reconstruction (TOR) problem, that is the so...
متن کاملDetermining Frequent Patterns of Copy Number Alterations in Cancer
Cancer progression is often driven by an accumulation of genetic changes but also accompanied by increasing genomic instability. These processes lead to a complicated landscape of copy number alterations (CNAs) within individual tumors and great diversity across tumor samples. High resolution array-based comparative genomic hybridization (aCGH) is being used to profile CNAs of ever larger tumor...
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ژورنال
عنوان ژورنال: International Journal of Data Mining and Bioinformatics
سال: 2016
ISSN: 1748-5673,1748-5681
DOI: 10.1504/ijdmb.2016.076017